“Study of association of serum lipid profile, IL-6, & ADMA levels with subclinical hypothyroidism”

Background & Objectives: Subclinical hypothyroidism (SCH) represents the mildest form of thyroid hormone deficiency and may be associated with adverse consequences. SCH is defined as an elevated serum thyrotropin (often referred to thyroid-stimulating hormone, or TSH) level normal levels free thyroxine (FT4) that affects up 10% adult population. The identification patients subclinical having increased cardiovascular risk great importance in present era. aim study was evaluate factors hypothyroidism.
 Methods: 120 age gender matched healthy euthyroid controls group 18-70 years were included study. Body mass index (BMI), lipid profile, biomarkers estimated both groups further compared using student t-test. Lipid profile also correlated ADMA IL-6 results analyzed Pearson’s correlation coefficient.
 Results: Patients had significantly higher TSH, ADMA. Similarly, total cholesterol (TC) low-density lipoprotein (LDL-C) HDL-C decreased when same parameters (p<0.001). Significant positive correlations found among ADMA.
 Conclusions: concluded presented concentrations disease (CVD) viz. IL-6, profile. potential benefits diagnosis treatment have possible advantages firstly by preventing progression overt secondly decrease death from starting appropriate therapy improve parameters.